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Journal of Antimicrobial Chemotherapy (1999) 43, Suppl. A, 25-30
© 1999 The British Society for Antimicrobial Chemotherapy

Determination of the antimicrobial susceptibilities of Canadian isolates of Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis

J. M. Blondeau*, M. Suter, S. Borsos and the Canadian Antimicrobial Study Group{dagger}

Division of Clinical Microbiology, Saskatoon District Health and St Paul's Hospital (Grey Nuns) and the Department of Pathology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

The susceptibility of Canadian isolates of three respiratory tract pathogens (Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae) to several antimicrobial agents were tested by two different methods. ß-Lactamase was produced by 68/211 (32.2%) of H. influenzae isolates and 64/75 (85.3%) of M. catarrhalis isolates. For S. pneumoniae, 19/156 (12.2%) isolates were resistant to penicillin (MIC >=0.12 mg/L) and two isolates had MICs of 1.5 mg/L. For some combinations of agents and organisms, different methods gave different values for the proportion of isolates susceptible. Regardless of methodology, for H. influenzae, the most active antimicrobials based on proportion of strains susceptible were ciprofloxacin (100%) and cefpodoxime (98.5- 100%). For M. catarrhalis, the most active agents were azithromycin, cefaclor, cefixime, cefpodoxime, cefuroxime, ciprofloxacin, clarithromycin and loracarbef (100% each); the least active was ampicillin. Against penicillin-sensitive and -resistant pneumococci, the activity was not significantly different for azithromycin and clarithromycin (93.4- 100%) and ciprofloxacin (MIC 90 2.0 and 1.5 mg/L, respectively) but was different for cefuroxime (99.3% and 31.6%, respectively), cefaclor (MIC 90 0.75 and >=256 mg/L, respectively), cefpodoxime (MIC 90 0.047 and 1.5 mg/L, respectively) and loracarbef (MIC 90 0.75 and >=256 mg/L, respectively). This study indicates the increasing incidence, in Canada, of ß-lactamase resistance in H. influenzae and M. catarrhalis and penicillin resistance in S. pneumoniae.

* Corresponding address: Department of Clinical Microbiology, Royal University Hospital, 103 Hospital Drive, Saskatoon, Saskatchewan, Canada, S7N 0W8. Tel: +1-306-655-6943; Fax: +1-306-655-6947; E-mail: blondeauj{at}sdh.sk.ca

{dagger} See Asknowledgements.


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