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Journal of Antimicrobial Chemotherapy (1999) 43, 837-839
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Antibacterial effect of garlic and omeprazole on Helicobacter pylori

D. Jonkersa,*, E. van den Broeka, I. van Doorena, C. Thijsb, E. Dorantb, G. Hagemanc and E. Stobberingha

a Department of Medical Microbiology, University Hospital Maastricht; b Department of Epidemiology and University of Maastricht, The Netherlands c Department of Health Risk Analysis and Toxicology, University of Maastricht, The Netherlands

The antibacterial effect of a home-made raw garlic extract and commercial garlic tablets alone and in combination with antibiotics or omeprazole was determined against clinical isolates of Helicobacter pylori. MIC values of raw garlic extract and three types of commercial garlic tablets ranged from 10,000 to 17,500 mg/L. When MIC values of the commercial tablets were based on the allicin content, no differences between the three types were observed. The combination of garlic and omeprazole, studied with killing curves, showed a synergic effect which was concentration dependent. Further clinical evaluation of garlic in combination with the conventional agents for H. pylori treatment seems warranted.

* Correspondence address. University Hospital Maastricht, Department of Medical Microbiology, PO Box 5800, 6202 AZ Maastricht, The Netherlands. Tel: +31-43-3874644; Fax: +31-43-3876643.


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