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Journal of Antimicrobial Chemotherapy (1999) 43, 805-809
© 1999 The British Society for Antimicrobial Chemotherapy

The postantibiotic effect of N-chlorotaurine on Staphylococcus aureus. Application in the mouse peritonitis model

Markus Nagla,*, Paul Hengsterb, Erich Semenitza,{dagger} and Waldemar Gottardia

a Institute for Hygiene, Leopold-Franzens-University of Innsbruck, Fritz-Pregl-Strasse 3, A-6010 Innsbruck; b University Hospital of Innsbruck, Department of Surgery, Anichstrasse 35, A-6020 Innsbruck, Austria

This study was designed to investigate the delay of regrowth (postantibiotic effect) in the presence of N-chlorotaurine (NCT), an endogenous active N-chlorine compound, of Staphylococcus aureus, strain Smith diffuse. The low reactivity of NCT enabled clear temporal separation of the postantibiotic and killing effect to be defined. Delay of regrowth proved to be dependent both on concentration of NCT, and incubation time. The maximum delay was 3 h. Using the model of lethal staphylococcal peritonitis in mice, in-vivo delay of regrowth of bacteria pretreated with N-chlorotaurine could be demonstrated to correlate with survival. It is concluded that the postantibiotic effect of N-chlorotaurine could be an important factor on decreasing virulence of bacteria. This effect was observed after relatively short incubation times.

* Corresponding author. Tel +43-512-507-3430; Fax: +43-512-507-2870; E-mail: waldemar.gottardi{at}uibk.ac.at

{dagger} Professor Erich Semenitz died in 1998 after the submission of this paper.


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