Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (23)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Manzoor, S. E.
Right arrow Articles by Fraise, A. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Manzoor, S. E.
Right arrow Articles by Fraise, A. P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (1999) 43, 759-765
© 1999 The British Society for Antimicrobial Chemotherapy

Reduced glutaraldehyde susceptibility in Mycobacterium chelonae associated with altered cell wall polysaccharides

S. E. Manzoora, P. A. Lambertb, P. A. Griffithsa, M. J. Gillc and A. P. Fraisea,*

a Hospital Infection Research Laboratory, City Hospital NHS Trust, Birmingham B18 7QH b Department of Pharmaceutical and Biological Sciences, University of Aston, Birmingham B4 7ET c Division of Immunity and Infection, University of Birmingham Medical School, Birmingham B15 2TT, UK

Glutaraldehyde-resistant Mycobacterium chelonae have been isolated from endoscope washer disinfectors and endoscope rinse water. The mechanism of glutaraldehyde resistance is not well understood. Two spontaneous, glutaraldehyde-resistant mutants of the sensitive type strain, NCTC 946, were investigated. The colony morphology of the two mutants differed from that of the the type strain: colonies of the former were dry and waxy whereas those of the latter were smooth and shiny. Increased resistance to glutaraldehyde of the mutants was matched by small increases in the MICs of rifampicin and ethambutol but not isoniazid. Both mutants showed increased surface hydrophobicity. No changes were identified in the extractable fatty acids or the mycolic acid components of the cell wall but a reduction in each of the resistant strains in the arabinogalactan/arabinomannan portion of the cell wall was detected.

* Corresponding author.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
Z. Svetlikova, H. Skovierova, M. Niederweis, J.-L. Gaillard, G. McDonnell, and M. Jackson
Role of Porins in the Susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to Aldehyde-Based Disinfectants and Drugs
Antimicrob. Agents Chemother., September 1, 2009; 53(9): 4015 - 4018.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
R. S. Duarte, M. C. S. Lourenco, L. d. S. Fonseca, S. C. Leao, E. d. L. T. Amorim, I. L. L. Rocha, F. S. Coelho, C. Viana-Niero, K. M. Gomes, M. G. da Silva, et al.
Epidemic of Postsurgical Infections Caused by Mycobacterium massiliense
J. Clin. Microbiol., July 1, 2009; 47(7): 2149 - 2155.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
B. E. Jonsson, M. Gilljam, A. Lindblad, M. Ridell, A. E. Wold, and C. Welinder-Olsson
Molecular Epidemiology of Mycobacterium abscessus, with Focus on Cystic Fibrosis
J. Clin. Microbiol., May 1, 2007; 45(5): 1497 - 1504.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
J. C. N. Shackelford, G. W. Hanlon, and J.-Y. Maillard
Use of a new alginate film test to study the bactericidal efficacy of the high-level disinfectant ortho-phthalaldehyde
J. Antimicrob. Chemother., February 1, 2006; 57(2): 335 - 338.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
S. Fraud, E. L. Rees, E. Mahenthiralingam, A. D. Russell, and J.-Y. Maillard
Aromatic alcohols and their effect on Gram-negative bacteria, cocci and mycobacteria
J. Antimicrob. Chemother., June 1, 2003; 51(6): 1435 - 1436.
[Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
P. C. Y. Woo, K.-W. Leung, S. S. Y. Wong, K. T. K. Chong, E. Y. L. Cheung, and K.-Y. Yuen
Relatively Alcohol-Resistant Mycobacteria Are Emerging Pathogens in Patients Receiving Acupuncture Treatment
J. Clin. Microbiol., April 1, 2002; 40(4): 1219 - 1224.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
A. P. Fraise
Biocide abuse and antimicrobial resistance--a cause for concern?
J. Antimicrob. Chemother., January 1, 2002; 49(1): 11 - 12.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.