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Journal of Antimicrobial Chemotherapy (1999) 43, 737-740
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Efficacy and pharmacodynamics of teicoplanin given daily during the first 3 days and then on alternate days for methicillin-resistant Staphylococcus aureus infections

Carlos Bantara,*, Ricardo Durlachb, Federico Nicolaa, Cristina Freulerb, Pablo Bonvehía, Raul Vazquezb and Jorgelina Smayevskya

a Departments of Microbiology and Infectious Diseases of the Centro de Educación Médica e Investigaciones Clínicas; b Hospital Alemán, Buenos Aires, Argentina

Fifteen evaluable patients (mean age, 67 years) were enrolled to assess the efficacy of teicoplanin, 6 mg/kg given daily during the first 3 days and then on alternate days, for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Eight patients had soft tissue infections, four catheter-associated bacteraemia, two osteomyelitis and one pneumonia. Clinical cure was observed in 13 of 15 patients. Both clinical and bacteriological failures were shown in the two patients with osteomyelitis. The mean serum levels of teicoplanin (mg/L) were 22, 8 and 6.7 for peak, 24 h and 48 h troughs, respectively. The dosage employed in this study proved effective in non-deep-seated MRSA infections.

* Correspondence address. Laboratorio de Bacteriología, Billinghurst 2447, Buenos Aires 1425, Argentina. Fax: +54-114-805-3233; E-mail: bantar{at}drwebsa.com.ar


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