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Journal of Antimicrobial Chemotherapy (1999) 43, 723-727
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Bioassays for itraconazole blood levels: an interlaboratory collaborative study

F. C. Oddsa,*, B. Dupontb, M. G. Rinaldic, D. A. Stevensd, D. W. Warnocke and R. Woestenborghsa

a Janssen Research Foundation, B2340 Beerse, Belgium; b Hôpital de l' Institut Pasteur, 75724 Paris, France; c Fungus Testing Laboratory, The University of Texas Health Science Center, San Antonio, TX 78284-7750; d Division of Infectious Diseases, Santa Clara Valley Medical Center and Stanford University Medical School, San Jose, CA 95128-2699, USA; e Mycology Reference Laboratory, Public Health Laboratory Service, Bristol BS2 8EL, UK

Duplicate bioassays for itraconazole and hydroxy-itraconazole were run with 30 serum samples in five laboratories, each using a different method. Both itraconazole and hydroxy- itraconazole were used as standards. Despite quantitative variations, the results of the bioassays correlated sufficiently to indicate the relative level of antifungal activity in the test samples.

* Corresponding author.


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