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Journal of Antimicrobial Chemotherapy (1999) 43, 715-718
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Co-amoxiclav affects cytokine production by human polymorphonuclear cells

Gigliola Reatob, Anna Maria Cuffinia,*, Vivian Tullioa, Angela Ianni Palarchioa, Alessandro Boninoa, Roberto Foab and Nicola A. Carlonea

a Department of Public Health and Microbiology, Microbiology Division; and b Biomedical Science and Human Oncology, University of Turin, Turin, Italy

Some antimicrobial agents have been reported to modify the host immune responses both in vivo and in vitro. As we demonstrated previously that co-amoxiclav had beneficial properties which result in enhancement of the microbicidal functions of human poly- morphonuclear cell (PMNs), we investigated the modulatory effect of this combination on cytokine production by human PMNs in vitro. The addition of co-amoxiclav elicited the production by lipopolysaccharide (LPS)-stimulated PMNs of substantial amounts of some cytokines, namely IL-8 and IL-1ß, after the addition of Klebsiella pneumoniae. These cytokine levels were higher than those obtained by PMNs incubated in culture medium only, without co-amoxiclav.

* Corresponding author. Department of Public Health and Microbiology, Microbiology Division, Via Santena 9, 10126 Torino, Italy. Tel: +39-11-670.6613; Fax: +39-11-66.36.436; E-mail: cuffini{at}molinette.unito.it


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