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Journal of Antimicrobial Chemotherapy (1999) 43, 579-582
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

The antifungal activity of mupirocin

R. O. Nicholasa,*, Valerie Berrya, Pamela A. Hunterb and Judy A. Kellyc

a SmithKline Beecham Pharmaceuticals, 1250 S. Collegeville Road, Collegeville, PA 19426, USA b Burnthouse, Burnthouse Lane, Cowfold, Sussex RH13 8DH c Schering Health Care, The Brow, Burgess Hill, West Sussex RH15 9NE, UK

The antibacterial agent mupirocin (pseudomonic acid A) is used as a topical agent in the treatment of superficial infections by Gram-positive bacteria, particularly Staphylococcus aureus. However, we demonstrate here that the compound also inhibits the growth of a number of pathogenic fungi in vitro, including a range of dermatophytes and Pityrosporum spp. It inhibited the incorporation of amino acids and precursors of RNA, but not that of acetate, by Trichophyton mentagrophytes. It also inhibited the isoleucyl-tRNA synthetase from Candida albicans, indicating a mechanism of action similar to that in bacteria. When administered topically, mupirocin was efficacious in a T. mentagrophytes ringworm model in guinea pigs. These results suggest that mupirocin could have clinical utility for superficial infections caused by dermatophytes.

* Corresponding author. Tel: +1-610-917-7000; Fax: +1-610-917-7901; E-mail: richard_o_nicholas{at}sbphrd.com


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