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Journal of Antimicrobial Chemotherapy (1999) 43, 555-558
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Correlation between genotype and ß-lactamases of clinical and environmental strains of Stenotrophomonas maltophilia

Miles Dentona,*, Valerie Keera and Peter M. Hawkeyb

a Department of Microbiology, The General Infirmary at Leeds, Great George Street, Leeds LS1 3EX b Department of Microbiology, University of Leeds, Leeds LS2 9JT, UK

Heterogeneity of ß-lactamase production by 17 clinical and nine environmental isolates of Stenotrophomonas maltophilia was investigated using MICs of six different ß-lactam antibiotics, isoelectric focusing (IEF) and pulsed field gel electrophoresis. There was no clear correlation between the results of IEF, genotype and MIC determination. Environmental isolates were more susceptible than clinical isolates; eight clinical and none of the environmental isolates expressed high-level resistance to meropenem. Only two isolates expressed high-level resistance to ceftazidime. These results indicate that further studies are required to elucidate the extent of genetic heterogeneity within the L1 and L2 ß-lactamase genes.

* Tel: +44-113-392-2922; Fax: +44-113-233-5649; E-mail: milesd{at}pathology.leeds.ac.uk


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