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Journal of Antimicrobial Chemotherapy (1999) 43, 273-276
© 1999 The British Society for Antimicrobial Chemotherapy

Brief reports

Prevalence and degree of expression of the carbapenemase gene (cfiA) among clinical isolates of Bacteroides fragilis in Nottingham, UK

R. Edwards*, C. V. Hawkyard, M. T. Garvey and D. Greenwood

Division of Microbiology and PHLS Laboratory, University Hospital, Queen':s Medical Centre, Nottingham NG7 2UH, UK

The carbapenemase gene (cfiA) was detected in 12 (6.9%) out of 175 clinical isolates of Bacteroides fragilis from Nottingham, three times the frequency reported from France. Only one gene copy was present in all cases. Eleven (6.3%) of the cfiA-positive isolates were susceptible to imipenem or meropenem (MIC < 8 mg/L); strains of this type have the potential to convert to high-level resistance. One isolate (0.6%) displayed resistance to both carbapenem antibiotics and was associated with specific carbapenemase activity six times that of the sensitive isolates.

* Tel: +44-115-9249924, ext. 42632; Fax: +44-115-9709233; E-mail: richard.edwards{at}nottingham.ac.uk


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