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Journal of Antimicrobial Chemotherapy (1999) 43, 177-185
© 1999 The British Society for Antimicrobial Chemotherapy

Review

The suppository form of antibiotic administration: pharmacokinetics and clinical application

E. Bergogne-Bérézina,* and A. Bryskierb

a Microbiology Department, Bichat-Claude Bernard University Hospital, 46 Rue Henri-Huchard, 75877 Paris Cedex 18; b Argenteuil Hospital, France

The rectal route of antibiotic administration might be used effectively when other routes of administration are inadequate or unsuitable. With the use of various adjuvants, the rectal route can provide satisfactory pharmacokinetics and acceptable local tolerance. Experiments in animals have demonstrated the influence of the pharmaceutical formulation of suppositories on the rectal absorption and systemic distribution of ß-lactams and aminoglycosides. In healthy volunteers and in children under treatment, similar adjuvants— mainly glyceride mixtures or non-ionic surface agents— have increased the rectal absorption of aminopenicillins, cephalosporins and macrolides. Other antibiotics, including metronidazole and co-trimoxazole, have been investigated in respect of their potential rectal administration.

* Tel: +33-1-40-25-85-27; Fax: +33-1-42-28-99-51


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