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Journal of Antimicrobial Chemotherapy, Vol 42, 831-834, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy

Incorporation rates, stabilities, cytotoxicities and release of liposomal tetracycline and doxycycline in human serum [In Process Citation]

L Sangare, R Morisset, A Omri and M Ravaoarinoro
Department of Microbiology and Immunology, University of Montreal, Quebec, Canada.

Tetracycline and doxycycline were encapsulated in cationic, anionic and neutral liposomes. The amounts of antibiotic encapsulated, the stability of each preparation at 4 degrees C for 4 weeks, and the kinetics of the release of entrapped drug into human sera were assessed by highperformance liquid chromatography. The toxicities of the liposome preparations on human erythrocytes and HeLa 229 cells were evaluated in vitro. The results showed that doxycycline was entrapped more efficiently than tetracycline, and that doxycycline-entrapped liposomes were more stable at 4 degrees C and in human sera, and less cytotoxic than tetracycline-entrapped liposomes.
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L. Sangare, R. Morisset, L. Gaboury, and M. Ravaoarinoro
Effects of cationic liposome-encapsulated doxycycline on experimental Chlamydia trachomatis genital infection in mice
J. Antimicrob. Chemother., March 1, 2001; 47(3): 323 - 331.
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