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Journal of Antimicrobial Chemotherapy, Vol 42, 825-829, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy

Killing kinetics of intracellular Afipia felis treated with amikacin [In Process Citation]

H Le Pocher, P Brouqui and D Raoult
Unite des Rickettsies, CNRS UPRESA 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France.

Afipia felis is a facultative intracellular bacterium which multiplies in macrophages following inhibition of phagosome-lysosome (P-L) fusion. When A. felis-infected cells are incubated for 72 h with various antibiotics, only aminoglycosides are found to be bactericidal. We therefore studied the killing of intracellular A. felis by amikacin, and its relationship with the restoration of P-L fusion. Amikacin reduced the number of A. felis from 8.5 x 10(5) to 3.5 x 102 cfu/mL within 94 h. P-L fusion was restored after 30-40 h of incubation with amikacin. Both mechanisms may participate in the intracellular killing of bacteria.
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