Journal of Antimicrobial Chemotherapy, Vol 42, 803-806, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
RR Reinert, JJ Schlaeger and R Lutticken
Two hundred representative isolates, including 26 strains of Streptococcus
pneumoniae with intermediate resistance to penicillin, were selected from a
collection obtained from blood cultures of patients with bacteraemic
pneumococcal pneumonia. The MICs of moxifloxacin (BAY 12-8039),
grepafloxacin, sparfloxacin, levofloxacin, ofloxacin, ciprofloxacin,
erythromycin, tetracycline and penicillin G were determined by a standard
agar dilution technique. Moxifloxacin had the highest in-vitro activity
against S. pneumoniae (MIC90 = 0.25 mg/L; MIC range 0.06-0.25 mg/L). The
MIC90 values were one dilution lower than those obtained with sparfloxacin
and grepafloxacin, three dilutions lower than those obtained with
levofloxacin, and four dilutions lower than those of ofloxacin and
ciprofloxacin.
Moxifloxacin: a comparison with other antimicrobial agents of in-vitro activity against Streptococcus pneumoniae [In Process Citation]
Institute of Medical Microbiology (National Reference Center for Streptococci), University Hospital (RWTH), Aachen, Germany. reinert@rwth-aachen.de
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