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Journal of Antimicrobial Chemotherapy, Vol 42, 803-806, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy


Moxifloxacin: a comparison with other antimicrobial agents of in-vitro activity against Streptococcus pneumoniae [In Process Citation]

RR Reinert, JJ Schlaeger and R Lutticken
Institute of Medical Microbiology (National Reference Center for Streptococci), University Hospital (RWTH), Aachen, Germany. reinert@rwth-aachen.de

Two hundred representative isolates, including 26 strains of Streptococcus pneumoniae with intermediate resistance to penicillin, were selected from a collection obtained from blood cultures of patients with bacteraemic pneumococcal pneumonia. The MICs of moxifloxacin (BAY 12-8039), grepafloxacin, sparfloxacin, levofloxacin, ofloxacin, ciprofloxacin, erythromycin, tetracycline and penicillin G were determined by a standard agar dilution technique. Moxifloxacin had the highest in-vitro activity against S. pneumoniae (MIC90 = 0.25 mg/L; MIC range 0.06-0.25 mg/L). The MIC90 values were one dilution lower than those obtained with sparfloxacin and grepafloxacin, three dilutions lower than those obtained with levofloxacin, and four dilutions lower than those of ofloxacin and ciprofloxacin.
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