Journal of Antimicrobial Chemotherapy, Vol 42, 787-791, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
JH Sloos, JA van de Klundert, L Dijkshoorn and CP van Boven
The susceptibility of two collections of coagulase-negative staphylococci
(CNS) isolated from clinical specimens for teicoplanin and vancomycin were
compared. They comprised 91 and 101 isolates, collected in 1985 and 1994
respectively, from different departments of a teaching hospital. MICs of
vancomycin and teicoplanin were determined by a modified Etest method.
Additionally, a disc diffusion test was performed for teicoplanin. All
isolates were susceptible to vancomycin (MIC < or = 4 mg/L). Two of the
91 isolates collected in 1985 were intermediate to teicoplanin (MIC between
8 and 32 mg/L), whereas in 1994 the number of intermediate isolates was 20
out of 101 (P < 0.01). The correlation between MICs, as determined by
the modified Etest assay, and disc diffusion zones was poor (r = -0.35).
Results show that resistance to teicoplanin in CNS has increased in the
study hospital over a period of 9 years. This increase is likely to be
correlated with the introduction of teicoplanin. Furthermore, a disc
diffusion method does not appear to be the first method of choice for
detection of strains of CNS with diminished susceptibility to teicoplanin.
Changing susceptibilities of coagulase-negative staphylococci to teicoplanin in a teaching hospital [In Process Citation]
Department of Medical Microbiology, Leiden University Medical Center, The Netherlands.
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