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Journal of Antimicrobial Chemotherapy, Vol 42, 665-667, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

Use of ketolides in combination with other drugs to treat experimental toxoplasmosis

FG Araujo, AA Khan, A Bryskier and JS Remington
Research Institute, Palo Alto Medical Foundation, CA, USA.

Because combination therapy is required to treat human toxoplasmosis, we examined combinations of the ketolides HMR 3004 and HMR 3647 with atovaquone, clindamycin or sulphadiazine in a murine model of toxoplasmosis. An oral dose of 50 mg/kg/day of HMR 3004 protected 30% of mice lethally infected with Toxoplasma gondii. The same dose protected 100% of infected mice when administered in combination with non-protective doses of atovaquone, clindamycin or sulphadiazine. Similar results were noted with 25 mg/kg/day of HMR 3647. These results demonstrate that these drug combinations are highly effective for treating toxoplasmosis in mice.
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G. Ackermann and A. C. Rodloff
Drugs of the 21st century: telithromycin (HMR 3647)--the first ketolide
J. Antimicrob. Chemother., March 1, 2003; 51(3): 497 - 511.
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