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Journal of Antimicrobial Chemotherapy, Vol 42, 643-646, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

In-vitro activity of sanfetrinem against isolates of Streptococcus pneumoniae and Staphylococcus aureus

AP Johnson, M Warner and DC Speller
Laboratory of Hospital Infection, Central Public Health Laboratory, Colindale, London, UK. ajohnson@phls.co.uk

The activity of sanfetrinem (previously GV104326), was assessed against 168 isolates of Streptococcus pneumoniae and 90 isolates of Staphylococcus aureus. These isolates included a range of serotypes or phage types, and varied in their susceptibility to other antibiotics. Sanfetrinem exhibited good anti-pneumococcal activity, with MIC90s of < or = 0.007 mg/L and 0.5 mg/L for penicillin-susceptible and penicillin- resistant isolates, respectively. Sanfetrinem was also active against methicillin-susceptible staphylococci (MIC90 = 0.06 mg/L). However, the MICs of sanfetrinem for isolates with methicillin MICs of 8-16 mg/L and > or = 32 mg/L were 0.25-1 mg/L and 8->32 mg/L, respectively.
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