Journal of Antimicrobial Chemotherapy, Vol 42, 591-595, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
KA Hammer, CF Carson and TV Riley
The in-vitro activity of a range of essential oils, including tea tree oil,
against the yeast candida was examined. Of the 24 essential oils tested by
the agar dilution method against Candida albicans ATCC 10231, three did not
inhibit C. albicans at the highest concentration tested, which was 2.0%
(v/v) oil. Sandalwood oil had the lowest MIC, inhibiting C. albicans at
0.06%. Melaleuca alternifolia (tea tree) oil was investigated for activity
against 81 C. albicans isolates and 33 non- albicans Candida isolates. By
the broth microdilution method, the minimum concentration of oil inhibiting
90% of isolates for both C. albicans and non-albicans Candida species was
0.25% (v/v). The minimum concentration of oil killing 90% of isolates was
0.25% for C. albicans and 0.5% for non-albicans Candida species.
Fifty-seven Candida isolates were tested for sensitivity to tea tree oil by
the agar dilution method; the minimum concentration of oil inhibiting 90%
of isolates was 0.5%. Tests on three intra-vaginal tea tree oil products
showed these products to have MICs and minimum fungicidal concentrations
comparable to those of non-formulated tea tree oil, indicating that the tea
tree oil contained in these products has retained its anticandidal
activity. These data indicate that some essential oils are active against
Candida spp., suggesting that they may be useful in the topical treatment
of superficial candida infections.
ORIGINAL ARTICLES
In-vitro activity of essential oils, in particular Melaleuca alternifolia (tea tree) oil and tea tree oil products, against Candida spp
Department of Microbiology, The University of Western Australia, The Queen Elizabeth II Medical Centre, Nedlands.
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