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Journal of Antimicrobial Chemotherapy, Vol 42, 393-395, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

Concurrent clarithromycin and cyclosporin A treatment

B Sadaba, A Lopez de Ocariz, JR Azanza, J Quiroga and JA Cienfuegos
Clinical Pharmacology Department, University Clinic of Navarra School of Medicine, Pamplona, Spain. bsadaba@unav.es

Although macrolides have been associated with significant pharmacokinetic interactions, clarithromycin is considered to have a low interaction capacity. In this study, six transplant recipients treated with cyclosporin A also received clarithromycin. In all patients, the dose of cyclosporin A had to be reduced by a mean of 33% per day depending on the macrolide dose. Normalization of the dosage parameters began on the fourth day after stopping clarithromycin treatment. Co-administration of cyclosporin A and clarithromycin may lead to increases in whole blood cyclosporin levels, and appropriate dose reductions should be considered.
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