Journal of Antimicrobial Chemotherapy, Vol 42, 389-392, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
PE Verweij, M Mensink, AJ Rijs, JP Donnelly, JF Meis and DW Denning
The in-vitro activity of amphotericin B, itraconazole and voriconazole
against 130 clinical and 20 environmental Aspergillus fumigatus isolates
was tested with an agar dilution method using RPMI 1640 medium.
Itraconazole-susceptible (AF71) and -resistant (AF90) isolates were
included in each test and all isolates were tested in duplicate. Geometric
mean MIC values (ranges) at 48 h and 72 h were, respectively, amphotericin
B, 0.91 (0.25-2) and 1.50 (1-4) mg/L; itraconazole, 0.25 (0.06-1) and 0.48
(0.125-8) mg/L; and voriconazole, 0.56 (0.25-8) and 0.78 (0.25-8) mg/L. The
reproducibility of the results was high for all drugs. In-vitro resistance
of A. fumigatus to the tested antifungal agents was uncommon and the MICs
of itraconazole were half those of voriconazole (P < 0.01).
ORIGINAL ARTICLES
In-vitro activities of amphotericin B, itraconazole and voriconazole against 150 clinical and environmental Aspergillus fumigatus isolates
Department of Medical Microbiology, University Hospital Nijmegen, The Netherlands. P.Verweij@mmb.azn.nl
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