Journal of Antimicrobial Chemotherapy, Vol 42, 245-248, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
CL Koch, P Derby and VR Abratt
One hundred and twenty-three anaerobic isolates from Cape Town, South
Africa, were tested in vitro against cefoxitin, chloramphenicol,
metronidazole, co-amoxiclav, benzylpenicillin and clindamycin. Forty- five
Gram-positive organisms were tested against RP59500 (a streptogramin).
Resistance in the Gram-positive isolates was as follows: of the Clostridium
perfringens isolates, 4% were resistant to benzylpenicillin and 4% to
clindamycin; of the Peptostreptococcus anaerobius isolates, 10% were
resistant to benzylpenicillin, 10% to cefoxitin and 10% to metronidazole;
of the isolates of Peptostreptococcus spp., 12% were resistant to
benzylpenicillin, 6% to metronidazole, 6% to chloramphenicol and 12% to
RP59500. Of the Gram- negative organisms, those in the Bacteroides fragilis
group were resistant to benzylpenicillin (83%), cefoxitin (5%), clindamycin
(5%) and co-amoxiclav (2%). One clindamycin-resistant B. fragilis isolate
carried a plasmid homologous to the ermF erythromycin resistance
determinant.
ORIGINAL ARTICLES
In-vitro antibiotic susceptibility and molecular analysis of anaerobic bacteria isolated in Cape Town, South Africa
Department of Microbiology, University of Cape Town, South Africa.
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