Journal of Antimicrobial Chemotherapy, Vol 42, 211-216, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
TS Yam, JM Hamilton-Miller and S Shah
Extracts of tea (Camellia sinensis) can reverse methicillin resistance in
methicillin-resistant Staphylococcus aureus (MRSA) and also, to some
extent, penicillin resistance in beta-lactamase-producing S. aureus. These
phenomena are explained by prevention of PBP2' synthesis and inhibition of
secretion of beta-lactamase, respectively. Synergy between beta-lactams and
tea extracts were demonstrated by disc diffusion, chequerboard titration
and growth curves. Partition chromatography of an extract of green tea on
Sephadex LH-20 yielded several fractions, one of which contained a
virtually pure compound that showed the above-mentioned activities, at
concentrations above about 2 mg/L. The observed activities are novel and
distinct from the previously reported direct antibacterial activity of tea
extracts. Prevention of PBP2' synthesis offers an interesting possible new
approach for the treatment of infections caused by MRSA.
ORIGINAL ARTICLES
The effect of a component of tea (Camellia sinensis) on methicillin resistance, PBP2' synthesis, and beta-lactamase production in Staphylococcus aureus
Department of Medical Microbiology, Royal Free Hospital School of Medicine, London, UK.
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