Journal of Antimicrobial Chemotherapy, Vol 42, 153-160, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
M Desai, T Buhler, PH Weller and MR Brown
The change in resistance of Burkholderia cepacia to ceftazidime and to
ciprofloxacin during the exponential phase and up to the onset of
stationary phase was assessed along the growth curve in batch culture. B.
cepacia was grown in planktonic culture and in a biofilm on a membrane
support. Resistance increased progressively during the exponential phase,
being increased by ten-fold about every four generations. Bacteria grown in
a biofilm were about 15 times more resistant than equivalent
planktonic-grown bacteria. The growth rate was not the key factor for the
development of resistance. The growth phase and the mode of growth have a
fundamental impact on the susceptibility of B. cepacia towards
antimicrobial agents. Bacteria growing at the same rate may differ greatly
in their resistance to antimicrobial agents.
ORIGINAL ARTICLES
Increasing resistance of planktonic and biofilm cultures of Burkholderia cepacia to ciprofloxacin and ceftazidime during exponential growth
Department of Cystic Fibrosis and Respiratory Medicine, Birmingham Children's Hospital, UK.
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