Journal of Antimicrobial Chemotherapy, Vol 42, 91-94, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
KL Oakley, CB Moore and DW Denning
The in-vitro activity of the triazole antifungal agent voriconazole was
compared with itraconazole and amphotericin B against 60 aspergillus
isolates. Susceptibility tests were performed using two methods: a
macrodilution and a microdulution method. For macrodilution methodology,
geometric mean (GM) MIC values and ranges were 0.4 and 0.125-4 mg/L for
voriconazole, 0.24 and 0.06-->16 mg/L for itraconazole, and 1.04 and
0.5-4 mg/L for amphotericin B. For the microdilution method, GM MICs and
ranges were 0.66 and 0.125-2 mg/L for voriconazole, 0.27 and 0.06-->16
mg/L for itraconazole, and 1.62 and 0.25-32 mg/L for amphotericin B. In
conclusion, voriconazole is active against Aspergillus spp. in vitro, and
at similar concentrations to itraconazole.
ORIGINAL ARTICLES
In-vitro activity of voriconazole against Aspergillus spp. and comparison with itraconazole and amphotericin B
Department of Medicine, University of Manchester School of Medicine, Hope Hospital, UK.
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