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Journal of Antimicrobial Chemotherapy, Vol 42, 83-86, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

Altered membrane permeability as the basis of bactericidal action of methdilazine

D Chattopadhyay, T Mukherjee, P Pal, B Saha and R Bhadra
Department of Cellular Biochemistry, Indian Institute of Chemical Biology, Calcutta, India.

The growth inhibition of Escherichia coli and Staphylococcus aureus was accompanied by significant release of K+ and UV-absorbing small molecules upon exposure to methdilazine, an extensively used phenothiazine antihistamine. A severe decrease in [U-14C] glucose uptake and a rapid efflux of hexose from sugar-preloaded bacteria were also observed but without visible cellular lysis. Considerable damage to membrane permeability by methdilazine was proposed to explain the rapid loss in cfu/mL of the bacteria.
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N. K. Dutta, K. Mazumdar, A. DasGupta, and S. G. Dastidar
Activity of the phenothiazine methdilazine alone or in combination with isoniazid or streptomycin against Mycobacterium tuberculosis in mice
J. Med. Microbiol., December 1, 2009; 58(12): 1667 - 1668.
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