Journal of Antimicrobial Chemotherapy, Vol 41, 5-12, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
RC Spencer
Toxin-producing Clostridium difficile is the commonest cause of nosocomial
diarrhoea and, as such, poses a major problem in our hospitals. The main
population susceptible to disease is the elderly, for reasons that remain
unclear. By contrast, carriage rates in neonates are high, but disease is
low. The organism also has a major clinical impact in the immunosuppressed
host, patients undergoing surgery (especially gastrointestinal) and those
with severe underlying disease and longer hospital stay. Other
interventions with high-risk associations are enemas, nasogastric and
gastrostomy tubes and anti- peristaltic drugs. Data on the associated costs
of C. difficile diarrhoea are not freely available, but one estimate is
that in an average-sized district general hospital, 100 cases of C.
difficile infection can be expected each year with an extra annual cost of
400,000 pound sterling and 2100 lost bed days.
ORIGINAL ARTICLES
Clinical impact and associated costs of Clostridium difficile- associated disease
Bristol Public Health Laboratory, Bristol Royal Infirmary, UK.
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