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Journal of Antimicrobial Chemotherapy, Vol 41, 47-57, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

The epidemiology and typing of Clostridium difficile

JS Brazier
Anaerobe Reference Unit, Public Health Laboratory, University Hospital of Wales, Heath Park, Cardiff, UK.

Clostridium difficile is normally a harmless environmental bacterium but, under certain circumstances, it can cause hospital outbreaks of disease. To understand the disease epidemiology, outbreaks have been investigated by many different methods. The phenotypic and genotypic approaches to typing are reviewed here and the epidemiology of C. difficile-associated disease is elucidated in light of recent information.
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