Journal of Antimicrobial Chemotherapy, Vol 41, 21-27, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
RC Spencer
High Clostridium difficile disease rates were originally associated with
clindamycin use, but this association has declined in recent years
following the decline in the clinical use of clindamycin, and disease is
now particularly associated with the use of broad-spectrum antibiotics,
especially the cephalosporins. There are now sufficient reports in the
literature to merit the discontinuation of the widespread use of
cephalosporins, especially in the elderly, by the substitution, wherever
possible, with antibiotics not associated with the promotion of C.
difficile-associated disease. Such agents include benzylpenicillin,
gentamicin, trimethoprim, ciprofloxacin and the ureido-penicillins.
Widespread education about the proper use of antibiotics in clinical
practice remains essential.
ORIGINAL ARTICLES
The role of antimicrobial agents in the aetiology of Clostridium difficile-associated disease
Bristol Public Health Laboratory, Bristol Royal Infirmary, UK.
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