Journal of Antimicrobial Chemotherapy, Vol 41, 93-97, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
DE Uip, AL Lima, VS Amato, M Boulos, VA Neto and D Bem David
In view of the action of newer macrolide antibiotics on intracellular
protozoa, we have investigated the efficacy of roxithromycin in the
treatment of cryptosporidiosis in 26 patients with AIDS. Cryptosporidiosis
was confirmed either by faecal examination for parasites (modified Kinyoun
method) or by detection of the parasite in biopsy material obtained by
colonoscopy. Patients received oral roxithromycin (300 mg bd) for 4 weeks.
Twenty-two patients completed the study. At the end of the study, 15
patients (68%) were considered to be cured and six patients (27%) improved,
and treatment failed in one patient (5%). We conclude that roxithromycin is
a useful treatment for diarrhoea caused by Cryptosporidium spp. associated
with AIDS.
ORIGINAL ARTICLES
Roxithromycin treatment for diarrhoea caused by Cryptosporidium spp. in patients with AIDS
Department of Infectious and Parasitic Diseases, Clinics Hospital of Sao Paulo University, Brazil.
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