Journal of Antimicrobial Chemotherapy, Vol 41, 47-49, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
HR Michie
The sepsis syndrome has proved to be one of the most difficult clinical
situations to replicate in animal models. The outcome of sepsis in patients
depends not only on the pathogens, sizes of bacterial challenge and
adequacy of treatment, but also on age, host defence mechanisms and
individual response to septic shock and multiple organ failure. Novel
immunomodulatory agents may control endotoxaemia or bacteraemia in animal
models but they have not proved effective in septic patients. This article
considers whether the principal problem lies in our interpretation of the
data from animal studies, or whether such models are unsuitable for
assessing new treatments for the sepsis syndrome.
ORIGINAL ARTICLES
The value of animal models in the development of new drugs for the treatment of the sepsis syndrome
Royal Bolton Hospital NHS Trust, UK.
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