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Journal of Antimicrobial Chemotherapy, Vol 41, 103-112, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

Management of multiple organ failure: guidelines but no hard-and-fast rules

M Singer
Bloomsbury Institute of Intensive Care Medicine, UCL Medical School, Rayne Institute, London, UK. m.singer@ucl.ac.uk

Multiple organ failure is the commonest cause of death in the intensive care unit setting. There are numerous precipitating factors including sepsis, trauma and pancreatitis. The resulting tissue hypoxia, exaggerated inflammatory response and generation of free oxygen radicals leads to tissue damage and organ dysfunction. No definitive treatment exists despite considerable efforts to find a 'magic bullet'. Management still revolves around support of organ function and prevention of iatrogenic complications until recovery occurs. An increasing emphasis is being placed on prevention of organ dysfunction, including maintenance of tissue oxygenation, nutrition and infection control.
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