Journal of Antimicrobial Chemotherapy, Vol 41, 1-7, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
PO Nystrom
Systemic inflammatory response syndrome (SIRS) is the clinical expression
of the action of complex intrinsic mediators of the acute phase reaction.
SIRS can be precipitated by events such as infection, trauma, pancreatitis,
and surgery. At times, SIRS can compromise the function of various organ
systems resulting in Multiple Organ Dysfunction Syndrome (MODS). SIRS and
MODS are graded expressions of the inflammation associated with acute
illness. Mild forms are frequent in general wards for both medical and
surgical patients but those with severe forms require intensive care.
Clinicians should learn to identify SIRS in their patients at an early
stage to determine the underlying cause and treatment before the SIRS
progresses to a more severe form.
ORIGINAL ARTICLES
The systemic inflammatory response syndrome: definitions and aetiology
Department of Surgery, University Hospital, Linkoping, Sweden. per.olof.nystrom@mtk.us.lio.se
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