Journal of Antimicrobial Chemotherapy, Vol 41, 489-492, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
I Brook and AE Gober
The effect on the nasopharyngeal bacterial flora of therapy for 10 days
with co-amoxiclav or cefprozil was studied in 50 children with acute otitis
media. Before therapy, potential pathogens (Streptococcus pneumoniae,
Haemophilus influenzae and Moraxella catarrhalis) were isolated in 14 (56%)
of those treated with co-amoxiclav and 15 (60%) of those treated with
cefprozil. Following therapy, the reduction in the number of these
pathogens was the same in the two groups. However, differences between the
groups were noted in the recovery of organisms with interfering capability,
namely alpha-haemolytic streptococci, Peptostreptococcus anaerobius and
Prevotella melaninogenica. Fifty interfering organisms were recovered from
each group before therapy. After therapy with co-amoxiclav or cefprozil
their number declined to 11 and 42, respectively (P< 0.001).
ORIGINAL ARTICLES
Bacterial interference in the nasopharynx following antimicrobial therapy of acute otitis media
Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA.
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