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Journal of Antimicrobial Chemotherapy, Vol 41, 485-488, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

Serum bactericidal activity of newer oral cephalosporins in healthy volunteers

M Dan, F Poch, A Edelman, J Asherov, H Hafely and Y Atzmon
Infectious Diseases Unit, The E. Wolfson Hospital, Holon, Israel.

The serum bactericidal activity of three oral cephalosporins was studied in 12 volunteers, after administration of single doses of cefuroxime axetil 250 mg, cefixime 200 mg, cefixime 400 mg and cefetamet pivoxil 500 mg. Serum bactericidal activity against clinical isolates of Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae and Klebsiella pneumoniae was measured by a standardized microdilution method. Cefuroxime axetil demonstrated the best bactericidal activity against Gram-positive organisms and cefixime was the most bactericidal against Gram-negative bacteria.
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