Journal of Antimicrobial Chemotherapy, Vol 41, 397-401, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
ME Klepser, EJ Wolfe and MA Pfaller
The activity of fluconazole and amphotericin B against three isolates of
Cryptococcus neoformans was evaluated, with fluconazole and amphotericin B
MICs of 2.0-4.0 mg/L and 1.0 mg/L respectively, using time-kill curve
methods. Fluconazole was fungistatic against all isolates tested (<99.9%
decrease in cfu from initial inoculum). The fungistatic activity of
fluconazole was not enhanced by increasing the concentration of antifungal
in solution. In contrast, amphotericin B was markedly fungicidal (> or =
99.9% decrease in cfu from initial inoculum). Both the rate and the extent
of amphotericin B activity were enhanced when drug concentration was
increased.
ORIGINAL ARTICLES
Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B against Cryptococcus neoformans
University of Iowa College of Pharmacy, Iowa City 52242, USA. michael.klepser@uiowa.edu
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