Journal of Antimicrobial Chemotherapy, Vol 41, 391-396, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
EJ Goldstein, DM Citron, M Hudspeth, SH Gerardo and CV Merriam
The activity of trovafloxacin and five other oral agents against 250
aerobic and 137 anaerobic strains isolated from human and animal bite
wounds was determined by an agar dilution method. Trovafloxacin was active
against all aerobic and fastidious facultative isolates at < or = 0.5
mg/L and all anaerobes at < or = 2 mg/L (Bacteroides tectum,
Porphyromonas salivosa and Prevotella heparinolytica, < or = 0.25 mg/L;
Porphyromonas spp., < or = 0.5 mg/L; Prevotella spp. and
peptostreptococci, < or = 2.0 mg/L), except Fusobacterium nucleatum and
other fusobacteria (MIC90 < or = 4 mg/L). Levofloxacin was generally one
to two dilutions more active than ofloxacin, while ciprofloxacin was active
against aerobes (MIC < or = 1 mg/L) but less active against anaerobic
strains (MIC90 < or = 16 mg/L).
ORIGINAL ARTICLES
Trovafloxacin compared with levofloxacin, ofloxacin, ciprofloxacin, azithromycin and clarithromycin against unusual aerobic and anaerobic human and animal bite-wound pathogens
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, CA 90404, USA.
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