Journal of Antimicrobial Chemotherapy, Vol 41, 357-366, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
H Siau and D Kerridge
The effect of drugs in combination on the growth of Candida glabrata was
studied in solid medium by demonstration of reduced or enhanced growth, and
in liquid medium by determination of interaction indices. Amphotericin B
and 5-fluorocytosine showed a synergic effect, while combinations of
amphotericin B and miconazole, and miconazole and 5- fluorocytosine
exhibited antagonistic effects. In addition, concentration-dependent
antagonism was observed amongst combinations of metabolic inhibitors,
between inhibitors of sterol biosynthesis (terbinafine, miconazole,
ketoconazole, clotrimazole, econazole, fluconazole, itraconazole and
amorolfine) and inhibitors of nucleic acid or protein biosynthesis
(5-fluorocytosine, 5-fluorouracil, rifampicin and chlortetracycline). This
antagonism was strain-specific, occurring with C. glabrata strain 4,
Saccharomyces cerevisiae strain 237 and Candida albicans strain 72R, but
not with C. albicans strain 6406 or Candida parapsilosis strain 3104.
ORIGINAL ARTICLES
The effect of antifungal drugs in combination on the growth of Candida glabrata in solid and liquid media
Department of Biochemistry, University of Cambridge, UK. hongsiau@hkusua.hku.hk
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