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Journal of Antimicrobial Chemotherapy, Vol 41, 293-296, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

In-vitro activities of paromomycin and lasalocid evaluated in combination against Cryptosporidium parvum

X You, RF Schinazi, MJ Arrowood, M Lejkowski, AS Juodawlkis and JR Mead
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Using a chemiluminescence immunoassay, paromomycin and lasalocid were shown to inhibit Cryptosporidium parvum growth in Madin-Darby canine kidney cells in a concentration-dependent manner. The median effective concentrations (EC50s) for paromomycin and lasalocid were 1184 mg/L and 0.4 mg/L, respectively. Neither drug was cytotoxic to host cells at concentrations up to five times their EC50s. Drug combination studies were conducted and the resulting data were analysed by the median- effect principle and combination index method. Statistically significant synergy was observed when combinations of paromomycin and lasalocid were used at ratios of 5000:1 and 2500:1. A possible mechanism for synergy is discussed.
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