Journal of Antimicrobial Chemotherapy, Vol 41, 285-288, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
ME Evans and WB Titlow
Seventeen methicillin-resistant Staphylococcus aureus (MRSA) with unique
genotypes were examined to determine if resistance occurs more frequently
with ciprofloxacin or levofloxacin. The mean single-step resistance rate to
4 x MIC of ciprofloxacin was 1.05 x 10(-5) (range <4.82 x 10[-11] to
5.06 x 10[-5]), and that to levofloxacin was 4.03 x 10(-6) (range <3.57
x 10[-13] to 4.10 x 10[-5]) (P < 0.05). When serially passaged, the mean
MICs of ciprofloxacin and levofloxacin increased 3.0 +/- 1.5-fold and 1.8
+/- 1.4-fold, respectively (P < 0.05). Only four strains became
resistant to levofloxacin, but eight became resistant to ciprofloxacin (P
< 0.05). Ciprofloxacin selects resistant MRSA more frequently than
levofloxacin.
ORIGINAL ARTICLES
Levofloxacin selects fluoroquinolone-resistant methicillin-resistant Staphylococcus aureus less frequently than ciprofloxacin
Department of Internal Medicine, University of Kentucky School of Medicine, Lexington 40536-0084, USA. meevan1@pop.uky.edu
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