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Journal of Antimicrobial Chemotherapy, Vol 41, 277-280, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

Sensitization of Burkholderia cepacia to antibiotics by cationic drugs

JM Rajyaguru and MJ Muszynski
Department of Pediatric Infectious Diseases, Arnold Palmer Hospital for Children and Women, Orlando, FL 32806, USA. Jayshree@orhs.org

Chlorpromazine and prochlorperazine have previously been shown to enhance the susceptibility of Burkholderia cepacia to aminoglycosides. To screen other non-antibiotic drugs containing similar amine (-N-CH3) groups, we examined a range of such agents that are in current clinical use for the treatment of non-infectious diseases, in combination with antibiotics that are ineffective against B. cepacia. At a concentration of 0.2 mM, theobromine, theophylline, trifluoperazine, fluophenazine and coumarin-152 significantly reduced (by four-fold) the MICs of gentamicin and ceftazidime. Theobromine and theophylline also reduced the MICs of amikacin and azithromycin.
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