Journal of Antimicrobial Chemotherapy, Vol 41, 253-258, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
H Dabernat, P Geslin, F Megraud, P Begue, J Boulesteix, C Dubreuil, F de La Roque, A Trinh and A Scheimberg
A multicentre, open-label, randomized study was performed in 501 out-
patients with acute otitis media, aged 6-36 months, to study the impact of
treatment with either cefixime suspension 8 mg/kg/day bd or co- amoxiclav
suspension 80 mg/kg/day tds for 10 days on nasopharyngeal carriage of
Streptococcus pneumoniae and Haemophilus influenzae. Of 426 patients with
nasopharyngeal cultures at entry to the trial, end of treatment and at
follow-up visit (35 days after inclusion), significant changes in carriage
of S. pneumoniae were observed. The proportion of penicillin-resistant S.
pneumoniae was higher in the samples taken at the end of treatment and
follow-up than in those taken at inclusion, while the total number of
children with this microorganism was lower. The difference at the end of
treatment was greater with co-amoxiclav than with cefixime. For H.
influenzae the resistance rate remained steady while the number of children
with this microorganism decreased. At follow-up there was no significant
difference between the two groups in terms of nasopharyngeal positive
culture for S. pneumoniae or H. influenzae. Despite these differences,
successful clinical responses were similar at the end of treatment and at
follow-up.
ORIGINAL ARTICLES
Effects of cefixime or co-amoxiclav treatment on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae in children with acute otitis media
Laboratoire Central de Microbiologie, CHU, Hopital Purpan, Toulouse, France.
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