Journal of Antimicrobial Chemotherapy, Vol 41, 247-251, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
YF Chiew, SF Yeo, LM Hall and DM Livermore
To test the widespread view that resistance disappears in the absence of
antimicrobial use, we tested streptomycin against 477 Enterobacteriaceae
from the Royal London Hospital. Twenty per cent proved resistant although
streptomycin is little used at the hospital and streptomycin resistance in
gram-negative bacteria is caused by mechanisms that do not compromise the
drugs that are used. Up to 70% of the observed resistance was associated
with cross-resistance to spectinomycin and the presence of ant(3")-Ia, an
integron-associated gene carried in Tn21-type transposons. This genetic
organization may have conserved streptomycin resistance in the absence of
direct selection pressure.
ORIGINAL ARTICLES
Can susceptibility to an antimicrobial be restored by halting its use? The case of streptomycin versus Enterobacteriaceae
Department of Medical Microbiology, St Bartholomew's and the Royal London School of Medicine and Dentistry, UK.
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