Journal of Antimicrobial Chemotherapy, Vol 41, 163-169, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
M Trautmann, R Zick, T Rukavina, AS Cross and R Marre
The influence of meropenem, a new carbapenem antibiotic, on cell morphology
and in-vitro lipopolysaccharide (LPS) release from Escherichia coli was
compared with that of imipenem, ceftazidime, tobramycin and ciprofloxacin.
Free and cell-associated LPS was quantified by means of a capture ELISA
method based on the recognition of E. coli LPS by monoclonal antibodies.
Microscopically, meropenem was found to induce spheroplast formation
similar to that seen with imipenem, while ceftazidime and ciprofloxacin
induced filament formation. Free and cell-associated LPS levels were low in
the presence of meropenem, imipenem, ciprofloxacin and tobramycin, but high
in the presence of ceftazidime. Reduced endotoxin release appears to be a
common property of carbapenem antibiotics. Morphological changes in
bacteria in the presence of antibiotics do not predict their LPS-
liberating effect since ciprofloxacin induced low levels of LPS despite
causing filament formation.
ORIGINAL ARTICLES
Antibiotic-induced release of endotoxin: in-vitro comparison of meropenem and other antibiotics
Department of Medical Microbiology and Hygiene, University of Ulm, Germany.
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