Journal of Antimicrobial Chemotherapy, Vol 41, 149-153, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
FJ Boswell, JM Andrews and R Wise
The pharmacodynamic properties of a novel ketolide (a new class of
macrolide), HMR 3647, were investigated by studying time-kill kinetics and
postantibiotic effect (PAE). The time-kill kinetics were studied at two
inocula against three strains each of Staphylococcus aureus, Haemophilus
influenzae, Moraxella catarrhalis, Streptococcus pneumoniae, Streptococcus
pyogenes, Enterococcus faecalis, Enterococcus faecium and Bacteroides
fragilis. The PAEs of HMR 3647 were also investigated on these organisms at
concentrations equivalent to 1, 4 and 10 x MIC. The time-kill kinetic data
demonstrated that HMR 3647 is predominantly bacteriostatic and only slowly
bactericidal at higher concentrations. HMR 3647 exhibited a significant PAE
with all strains studied, ranging from 1.2 h to 8.2 h at 10 x MIC. The
bacteriostatic activity and significant PAE demonstrated by HMR 3647 are
similar to those previously obtained with other macrolides.
ORIGINAL ARTICLES
Pharmacodynamic properties of HMR 3647, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time-kill kinetics and postantibiotic effect
Department of Medical Microbiology, City Hospital NHS Trust, Birmingham, UK.
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