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Journal of Antimicrobial Chemotherapy, Vol 41, 119-121, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy


ORIGINAL ARTICLES

A plasmid-mediated beta-lactamase conferring resistance to cefotaxime in a Salmonella typhimurium clone found in St Petersburg, Russia

M Gazouli, SV Sidorenko, E Tzelepi, NS Kozlova, DP Gladin and LS Tzouvelekis
Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.

Four clinical and two environmental isolates of cefotaxime-resistant Salmonella typhimurium strains collected in St Petersburg, Russia, were studied. Molecular typing demonstrated that they constituted a single clone. The isolates expressed a cefotaxime-hydrolysing beta-lactamase with a pl of 8.4. The enzyme was encoded by a 12 kb plasmid which did not hybridize with TEM, SHV or ampC probes.
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