Journal of Antimicrobial Chemotherapy, Vol 41, 111-114, Copyright © 1998 by The British Society for Antimicrobial Chemotherapy
M Oethinger, WV Kern, JD Goldman and SB Levy
Fluoroquinolone resistance in Escherichia coli is principally caused by two
kinds of mutation: those affecting the target proteins of the drugs, i.e.
DNA gyrase and topoisomerase IV, and those affecting regulatory genes such
as marA, soxS or robA. Recently, overexpression of the latter genes was
linked to increased organic solvent tolerance in E. coli. Among 138
clinical fluoroquinolone-resistant and - susceptible clinical isolates of
E. coli we found a high association between fluoroquinolone resistance and
organic solvent tolerance. This finding suggests that E. coli may undergo
an adaptive response to extrinsic substances other than quinolones, while
mutating to fluoroquinolone resistance.
ORIGINAL ARTICLES
Association of organic solvent tolerance and fluoroquinolone resistance in clinical isolates of Escherichia coli
Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, MA, USA.
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