Journal of Antimicrobial Chemotherapy, Vol 40, 93-98, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
J Ferguson and R Dawe
Skin photosensitizing reactions have been reported during treatment with
fluoroquinolone antibiotics. The incidence and severity of such reactions,
however, appear to differ between agents. The photosensitizing effect of
grepafloxacin 400 and 600 mg once daily was compared with that of
ciprofloxacin 500 mg bd and placebo in a double- blind trial involving 32
healthy subjects. Skin photosensitivity, expressed as the minimal erythemal
dose (MED), was measured before treatment and towards the end of the 7 day
treatment period. Grepafloxacin showed a mild photosensitizing effect
comparable to that of ciprofloxacin, with significant reductions in MED at
335+/-30 and 365+/-30 nm. However, few subjects showed MEDs outside the
normal range, and MEDs consistently returned to baseline values within 1
week of stopping treatment. No significant differences between the effects
of grepafloxacin and ciprofloxacin could be observed. It is concluded that
grepafloxacin has a weak, UVA-dependent and rapidly reversible
photosensitizing effect.
ORIGINAL ARTICLES
Phototoxicity in quinolones: comparison of ciprofloxacin and grepafloxacin
Department of Dermatology, Ninewells Hospital, Dundee, UK.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. E. Falagas, D. K. Matthaiou, and K. Z. Vardakas Fluoroquinolones vs {beta}-Lactams for Empirical Treatment of Immunocompetent Patients With Skin and Soft Tissue Infections: A Meta-analysis of Randomized Controlled Trials Mayo Clin. Proc., December 1, 2006; 81(12): 1553 - 1566. [Abstract] [Full Text] [PDF]
|
|