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Journal of Antimicrobial Chemotherapy, Vol 40, 881-883, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

In-vitro susceptibility of Helicobacter pylori to ampicillin, clarithromycin, metronidazole and omeprazole

VG Loo, CA Fallone, E De Souza, J Lavallee and AN Barkun
Department of Microbiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.

The in-vitro activities of omeprazole and three antimicrobial agents against 89 clinical isolates of Helicobacter pylori from a population with duodenal ulcer disease were determined by an agar dilution method. Resistance rates were 20% for metronidazole (MIC > 8 mg/L), 1% for clarithromycin (MIC > 2 mg/L) and zero for ampicillin (MIC > 8 mg/L). Omeprazole was relatively active against H. pylori in vitro (MIC < or = 8 mg/L).
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