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Journal of Antimicrobial Chemotherapy, Vol 40, 295-297, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

ORIGINAL ARTICLES

Enhanced pulmonary accumulation of liposomal amphotericin B (AmBisome) in acute liver transplant failure

V Heinemann, D Bosse, U Jehn, A Debus, K Wachholz, H Forst and W Wilmanns
Klinikum Grosshadern, III Medical Clinic, University of Munich, Germany.

Plasma and tissue concentrations of amphotericin B were determined in a patient treated with liposomal amphotericin B during liver transplant failure. A cumulative rise in amphotericin B plasma concentrations was observed accompanied by an enhanced pulmonary deposition of the drug. Failure of the liver as a major component of the reticuloendothelial system may cause elevated plasma concentrations of liposomal amphotericin B and may consequently enhance deposition of liposomes in the lungs as a substitutive clearing organ.
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