Journal of Antimicrobial Chemotherapy, Vol 40, 283-286, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
J Versalovic, MS Osato, K Spakovsky, MP Dore, R Reddy, GG Stone, D Shortridge, RK Flamm, SK Tanaka and DY Graham
Fifty-four of 59 (91.5%) clarithromycin-resistant isolates of Helicobacter
pylori from different patients possessed either the A2143G (formerly
A2058G) or the A2144G (formerly A2059G) mutation in the gene encoding 23S
rRNA. The A2143G mutation was significantly more likely to occur in
isolates with MICs exceeding 64 mg/L (65% versus 30% with the A2144G
mutation; P = 0.01). The majority (26 of 31; 83.9%) of isolates with the
A2143G mutation had MICs exceeding 64 mg/L. Peptic ulcer disease recurred
in a substantial proportion of patients infected with H. pylori strains
containing either the A2143G or the A2144G mutation.
ORIGINAL ARTICLES
Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance
Digestive Diseases, Veterans Affairs Medical Center, Houston, TX 77030, USA. jversal@tiac.net
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